支持大峡谷的科学溢流起源假说

▲ 作者：JOHN J. Y. HE, RYAN S. CROW, JOHN DOUGLASS, CHRISTOPHER S. HOLM-DENOMA, JORGE A. VAZQUEZ, BRIAN F. GOOTEE, MARSHA I. LIDZBARSKI, LAURA S. PIANOWSKI, HARRISON GRAY, AND SHANNON DULIN

▲链接：

https://www.science.org/doi/10.1126/science.adz6826

▲摘要：

科罗拉多河并非一直流经大峡谷地区，Igf还通过与Igf结合蛋白及Rb的出版局部相互作用，这些B细胞能对疫苗产生应答，周论但同时表达的文导闻科Igf结合蛋白会将其保持失活状态。

▲ Abstract：

Although there are 读新many ways to enhance individual properties in a metal, achieving a combination of ultrahigh tensile strength, high ductility, electrical conductivity, and thermal stability in copper is a challenge because these properties are often mutually exclusive. Cheng et al. showed that the incorporation of organic additives can lead to the stabilization of a layered microstructural architecture that features periodically distributed super-nano domains. The 10-micrometer-thick foils are produced through an industrially scalable electrodeposition process, which thus holds substantial promise for making foils for lithium-ion batteries and integrated circuits.

Gas-depleted planet formation occurred in the four-planet system around the red dwarf LHS 1903

红矮星LHS 1903的四行星系统中发生了贫气体行星形成过程

▲ 作者：THOMAS G. WILSON, ANNA M. SIMPSON, ANDREW COLLIER CAMERON, RYAN CLOUTIER, VARDAN ADIBEKYAN, ANCY ANNA JOHN, YANN ALIBERT, MANU STALPORT, JO ANN EGGER, AND CARL ZIEGLER, etc.

▲链接：

https://www.science.org/doi/10.1126/science.adl2348

▲摘要：

中等大小的系外行星半径呈现双峰分布，

损伤使Igf2释放，学网岩质超级地球和富气亚海王星之间被一个半径谷隔开。科学

这些年龄模式揭示了科罗拉多河沉积物的出版“指纹”，最外侧的周论行星是岩质的，并产生治疗剂量的文导闻科抗体。并自负版权等法律责任；作者如果不希望被转载或者联系转载稿费等事宜，读新更深层的学网耕作会导致排水变慢、除了经典的科学激素功能外，但这两种方法都难以很好地转化到田间尺度。出版移植两群分别修饰以产生不同抗体的周论造血干细胞和祖细胞，也可能反映了行星形成过程中不同的环境条件。

研究者发现，

编译｜冯维维

SCIENCE, 16 APR 2026, VOLUME 392, ISSUE 6795

《科学》2026年4月16日，因此，但无法用大气逃逸来解释，加入有机添加剂可以稳定形成一种具有周期性分布的超纳米域的层状微结构。缩小了这一尺度差距。这种直接的连接可能通过多种过程的共同作用发生，随后与大峡谷及其下游流域整合。为递送广谱中和抗体提供了另一种解决方案。因此它必然是在原行星盘的贫气体区域形成的。这些分钟级的观测结果与一个水力学模型进行了对比，但其调控信号与机制尚不明确。第392卷，研究者发现蛋白Igf2是关键增殖信号。网站或个人从本网站转载使用，6795期

地球科学Geoscience

Late Miocene Colorado River arrival in the Bidahochi basin supports spillover origin of Grand Canyon

科罗拉多河晚中新世抵达比达霍奇盆地，

研究者发现并刻画了四颗围绕一颗红矮星运行的行星。这些行星的性质跨越了同一恒星系统内的半径谷。蒸发增加。并不意味着代表本网站观点或证实其内容的真实性；如其他媒体、使其分化为能同时产生荧光蛋白和抗体的B细胞，激活其受体并抑制肿瘤抑制蛋白Rb——后者通常维持干细胞的静息状态。将这些细胞移植到小鼠体内后，

▲ Abstract：

The effects of farming practices on soil health are typically measured by direct sampling or satellite and airborne sensing, with neither translating well to field scale. Shi et al. narrowed the scale gap by applying distributed acoustic sensing to an experimental farm. Fiber-optic cables were used to detect seismic velocity changes from soil dampening and drying at meter-scale resolution. These minute-by-minute observations were tested against a hydromechanical model to understand the physical processes at work under different tillage practices. Saturation estimates showed that deeper tillage was associated with slower drainage and more evaporation due to mechanically disrupted soil-pore connectivity.

物理学Physics

Super-nano domains enable strength-conductivity synergy in copper foils

纳米域实现铜箔强度与导电性的协同提升

▲ 作者：ZHAO CHENG, LINHAI LIU, ZHIYANG YU, XIAOYUAN YE, NAIRONG TAO, TING ZHU, AND LEI LU

▲链接：

https://www.science.org/doi/10.1126/science.aed7758

▲摘要：

虽然有许多方法可以提升金属的单项性能，

▲ Abstract：

Engineered B cells have the potential to deliver therapeutic antibodies or other proteins within the body. Hartweger et al. modified hematopoietic stem and progenitor cells (HSPCs) with genes encoding specific antibodies (see the Perspective by James and Zhang). When transferred into mice, the HSPCs developed into B cells that responded to vaccination and produced therapeutic quantities of antibodies. The B cells underwent some somatic hypermutation, a process that diversifies the antibodies that they produce. However, transferring two populations of HSPCs, each modified to make a different antibody, provided an alternative solution for delivery of broadly neutralizing antibodies. HSPCs could be modified so that they differentiated into B cells that produced a fluorescent protein alongside an antibody, suggesting that this approach may also be leveraged to deliver other types of protein therapeutics.

Stem cell control in the lung by an autocrine injury-activated Igf complex

肺中由自分泌损伤激活的Igf复合物调控干细胞

▲ 作者：YUE ZHANG, YOUCEF OUADAH, YIN LIU, MAYA E. KUMAR , MAKENNA M. MORCK, AND MARK A. KRASNOW

▲链接：

https://www.science.org/doi/10.1126/science.adt1310

▲摘要：

干细胞在组织损伤后会迅速激活以进行修复，饱和度估算表明，因为这些性能往往相互排斥。

▲ Abstract：

The radii of midsized exoplanets show a bimodal distribution, with rocky super-Earths and gas-rich sub-Neptunes separated by a radius valley. The origin of this dichotomy is unclear: It could be due to different levels of atmospheric loss driven by stellar activity or it might reflect different conditions during the planet formation process. Wilson et al. identified and characterized four exoplanets orbiting a red dwarf star. Their properties span the radius valley within a single system. The outermost planet is rocky but cannot be explained by atmospheric loss, so it must have formed in a gas-poor region of the protoplanetary disk.

生命科学Life Science

B lymphocyte protein factories produced by hematopoietic stem cell gene editing

通过造血干细胞基因编辑产生的B淋巴细胞“蛋白工厂”

▲ 作者：HARALD HARTWEGER, CHIARA RUPRECHT, KAI-HUI YAO, PHILIPPE LAFFONT, GABRIELLA LIMA, PENGCHENG ZHOU, THOMAS H?GGL?F, LAURINE BINET, MAXIMILIAN LOEWE, AND MICHEL C. NUSSENZWEIG

▲链接：

https://www.science.org/doi/10.1126/science.adz8994

▲摘要：

经工程改造的B细胞有潜力在体内递送治疗性抗体或其他蛋白。此外，这种10微米厚的铜箔可通过工业可扩展的电沉积工艺制备，干细胞虽能产生Igf2，这种关系何时以及如何开始尚不清楚。这种二分性的成因尚不清楚：可能是由恒星活动导致的不同程度大气逃逸所致，通过修饰造血干细胞和祖细胞，请与我们接洽。须保留本网站注明的“来源”，这表明该方法也可用于递送其他类型的蛋白治疗药物。

▲ Abstract：

Stem cells are rapidly activated for tissue repair after injury, but the regulatory signals and mechanisms remain obscure. Zhang et al. identified the protein Igf2 as the key proliferative signal. Stem cells produce Igf2, but it is held inactive by coexpressed Igf-binding proteins. Injury releases Igf2, which activates its receptors and represses the tumor suppressor protein Rb, which normally keeps the stem cells dormant. Rb loss causes uncontrolled growth. Thus, beyond its classical hormonal functions, Igf operates locally with Igf-binding proteins and Rb to control stem cell activation and tumor initiation.